Betaderm Cream 15g (Betamethasone Valerate) – Atco
Used For
Eczema
How it works
Topical corticosteroids act as anti-inflammatory agents via multiple mechanisms to inhibit late phase allergic reactions including decreasing the density of mast cells, decreasing chemotaxis and activation of eosinophils, decreasing cytokine production by lymphocytes, monocytes, mast cells and eosinophils, and inhibiting the metabolism of arachidonic acid.
Usage And Safety
Dosage
Adults & Children : Apply sparingly two or three times daily. OR As directed by your physician.
Side Effects
Common: may affect up to 1 in 10 people • local skin burning or pain • itchy skin Very rare: may affect up to 1 in 10,000 people : Use for a long period of time, or use under an airtight dressing, may cause the following symptoms: • increased weight • rounding of the face/moon face • obesity • thinning of your skin, this may cause stretch marks and it may also damage more easily • skin wrinkling
Drug Interactions
Ritonavir and itraconazole
Indication
It is used to help reduce the redness and itchiness of certain skin problems, such as eczema, psoriasis and dermatitis.
Precautions
Take care when applying to the eyelids to make sure it does not get into your eye as there may be a risk of developing glaucoma.
Warnings
Take care when applying to the face over a long period of time as it may cause skin thinning.
If you are using this for a prolonged period of time there is a possibility you may develop a cataract (clouding of the eye’s lens).
Take care if you are using large quantities for a prolonged period or you are treating a large area of the body. This medicine may be absorbed through the skin and into your blood stream which can result in the following symptoms of hypercortisolism developing; stretch marks, the appearance of blood vessels under the surface of your skin, increased body hair growth, changes in skin colour, skin thinning, weight gain or rounding of the face (moon face).
Additional Information
Pregnancy category
Always consult your physician before using any medicine.
Storage (YES/NO)
Store this medicine at room temperature, away from direct light and heat.
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Kenacomb Cream – GSK
KENACOMB combines the potent corticosteroid triamcinolone acetonide with the antifungal antibiotic nystatin and the wide spectrum antibacterial activity of neomycin and gramicidin.
KENACOMB reduces inflammation, relieves pruritis and combats or prevents monilial and bacterial infections.
Pharmacokinetics
The extent of percutaneous absorption of topical corticosteroids is determined by many factors including the vehicle, the integrity of the epidermal barrier, and the use of occlusive dressings.
Topical corticosteroids can be absorbed from normal intact skin, inflammation and/or other disease processes in the skin increase percutaneous absorption.
Nystatin and gramicidin are not absorbed from intact skin or mucous membranes.
Neomycin can be absorbed through inflamed skin. Once absorbed, it is rapidly excreted unchanged through the kidneys. The half-life is approximately 2 to 3 hours.
Microbiology
Nystatin acts by binding to sterols in the cell membrane of susceptible species resulting in a change in membrane permeability and the subsequent leakage of intracellular components.
Nystatin exhibits no activity against bacteria, protozoa, or viruses.
Neomycin exerts its bacterial activity against a number of gram-negative organisms by inhibiting protein synthesis. It is not active against Pseudomonas aeruginosa, and resistant strains of gram-negative bacteria may develop.
Gramicidin exerts its antibacterial activity against many gram-positive organisms by altering cell membrane permeability.
INDICATIONS
KENACOMB is indicated for use in corticosteroid responsive dermatoses complicated or threatened by secondary monilial and/or bacterial infections, such as:
Atopic dermatitis
Seborrhoeic dermatitis
Lichen simplex chronicus
Psoriasis (particularly of the face and body folds)
Allergic contact dermatitis
KENACOMB CREAM permits use in moist intertrigenous areas.
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