Pain & Inflammation How it works Aceclofenac works by blocking the production of hormone-like substances called prostaglandins. Prostaglandins have many functions in the body including an important role in both the way the body responds to inflammation and also the reabsorption of calcium in some diseases of the bone. Usage And Safety Dosage The recommended dose in adults is 200 mg a day. One 100mg tablet should be taken in the morning and one in the evening. Children : Not Recommended. Always consult your doctor or pharmacist for dose adjustments. Side Effects Common ( may affect up to 1 in 10 people): • dizziness • nausea (feeling sick) • diarrhoea • increased liver enzymes in the bloodUncommon ( may affect up to 1 in 100 people): • wind • inflammation or irritation of the lining of the stomach • constipation • vomiting • mouth ulcers • itching • rash • inflammation of the skin . Rare ( may affect up to 1 in 1,000 people): • hypersensitivity (allergic reaction) • problems with eyesight • heart failure • high blood pressure shortness of breath • bleeding from the stomach or bowel • stomach or bowel ulceration Drug Interactions Selective serotonin-reuptake inhibitors (SSRIs) such as citalopram, escitalopram, fluoxetine, fluvoxamine, paroxetine and sertraline) or manic depression (lithium) , cardiac glycosides such as digoxin , (antihypertensives: ACE inhibitors such as enalopril, lisinopril; angiotensin II receptor antagonists such as losartan, candesartan; also hydralazine, methyldopa, clonidine, moxonidine, propranalol) , quinolone antibiotics such as ciprofloxacin, ofloxacin, levofloxacin , moxifloxacin , thiazides,furosemide amiloride hydrochloride , warfarin, heparin , methotrexate , mifepristone , (glucocorticoids such as hydrocortisone,prednisolone,) ciclosporin or tacrolimus , glibenclamide, glicazide, tolbutamide , clopidogrel. Indication Aceclofenac is used to relieve pain and reduce redness and swelling (inflammation) in patients suffering from: • Arthritis of the joints (osteoarthritis). This commonly occurs in patients over the age of 50 and causes the loss of the cartilage and bone tissue next to the joint. • Autoimmune disease that causes chronic inflammation of the joints (rheumatoid arthritis). • Arthritis of the spine which can lead to the fusion of the vertebrae (ankylosing spondylitis). When not to Use Do not take Aceclofenac : • If you are allergic to aceclofenac or any of the other ingredients of this medicine , if you areallergic to aspirin or any other NSAIDs (such as ibuprofen, naproxen or diclofenac).• If you have taken aspirin or any other NSAIDs and experienced one of the following:- Asthma attack causing tightness in the chest wheezing and difficulty breathing.- Runny nose, itching and/or sneezing (irritation of the nose).- Raised red circular patchy rash on the skin which may have felt itchy or like a sting or burn .- A severe allergic reaction known as anaphylactic shock. The symptoms may be life threatening and include difficulty breathing, wheezing, abdominal pain and vomiting . Precautions Precaution Caution should be excercised in patients with history of coagulation defects and history of liver dysfunstion. Warnings Aceclofenac may cause severe bleeding when taken for a long time. Elderly populations with a history of gastrointestinal disease are at higher risk. If you are taking Aceclofenac and you experience dizziness, drowsiness, vertigo, tiredness or any difficulty with your eyesight, you must not drive or use machinery. Aceclofenac is not recommended if you have impaired kidney function. Additional Information Pregnancy category Always consult your physician before using any medicine.