Bactroban Cream ( Mupirocin ) GSK

Mupirocin is used to treat certain skin infections (such as impetigo). It is an antibiotic. It works by stopping the growth of certain bacteria. How to use Bactroban topical Read the Patient Information Leaflet if available from your pharmacist before you start using mupirocin and each time you get a refill. If you have any questions, ask your doctor or pharmacist. Use this medication only on the skin. Clean and dry the affected area first. Then apply a small amount of ointment to the area as directed by your doctor, usually 3 times a day. You may cover the treated area with a bandage. Use this medication regularly to get the most benefit from it. Continue to use it for the full time prescribed, even if symptoms disappear after a few days. Stopping the medication too early may result in a return of the infection. Avoid using this medication around your eyes, nose, mouth, or on large areas of damaged or broken skin unless otherwise directed by your doctor. If you accidentally get it in your eyes, nose, or mouth, rinse well with plenty of water.

Barforte Eye Drops, 5 ml (Prednisolone) – Barrett Hodgson

Barforte Eye Drops contain Prednisolone Acetate 1% (10 mg/ml), a potent corticosteroid ophthalmic suspension used to treat steroid-responsive inflammatory conditions of the eye. It helps reduce redness, swelling, irritation, pain, and inflammation caused by allergies, eye injuries, certain eye diseases, or following eye surgery.

By suppressing the body's inflammatory response, Barforte Eye Drops provide targeted relief directly at the site of inflammation, helping improve comfort and support the healing process. This medicine should only be used under the supervision of an eye specialist.


Key Benefits

  • Effectively reduces moderate to severe eye inflammation.
  • Relieves redness, swelling, pain, and irritation.
  • Helps manage inflammation after eye surgery or ocular trauma.
  • Useful in treating steroid-responsive allergic and inflammatory eye conditions.
  • Delivers the medication directly to the affected eye for fast, localized action.
  • Supports recovery while minimizing inflammatory damage to eye tissues.

Composition

Each 1 ml contains:

  • Prednisolone Acetate BP10 mg (1% w/v)

Indications

Barforte Eye Drops are indicated for the treatment of steroid-responsive inflammatory conditions of the eye, including:

  • Allergic conjunctivitis
  • Anterior uveitis
  • Keratitis (when corticosteroid therapy is appropriate)
  • Iritis and iridocyclitis
  • Post-operative inflammation following eye surgery
  • Inflammation due to eye injury or trauma
  • Other inflammatory disorders of the anterior segment of the eye, as prescribed by an ophthalmologist

How It Works

Prednisolone Acetate is a corticosteroid that works by inhibiting the release of inflammatory chemicals responsible for redness, swelling, pain, and irritation. It reduces the body's immune response within the eye, helping control inflammation and prevent further tissue damage.


Directions for Use

  • Use only as directed by your doctor.
  • Shake the bottle well before each use, as it is an ophthalmic suspension.
  • Wash your hands before applying the drops.
  • Instill the prescribed number of drops into the affected eye(s).
  • Avoid touching the dropper tip to the eye or any surface to prevent contamination.
  • If using more than one eye medication, allow at least 5–10 minutes between applications.

Precautions

  • For ophthalmic use only.
  • Do not use if you have untreated viral, fungal, or certain bacterial eye infections unless advised by your doctor.
  • Prolonged use may increase intraocular pressure and the risk of glaucoma or cataract formation.
  • Do not wear contact lenses during treatment unless your doctor advises otherwise.
  • Inform your doctor if you are pregnant, breastfeeding, or have a history of glaucoma or eye infections.
  • Do not stop treatment abruptly without medical advice if used for an extended period.

Possible Side Effects

Some patients may experience:

  • Temporary burning or stinging after application
  • Blurred vision immediately after instillation
  • Eye irritation or discomfort
  • Increased intraocular pressure with prolonged use
  • Delayed wound healing
  • Cataract formation or secondary eye infections with long-term use

Seek immediate medical attention if you experience severe eye pain, vision changes, persistent redness, or signs of an allergic reaction.


Storage Instructions

  • Store below 25°C in a cool, dry place.
  • Protect from direct sunlight and excessive heat.
  • Keep the bottle tightly closed when not in use.
  • Keep out of the reach of children.
  • Do not use after the expiry date.

Disclaimer

Barforte Eye Drops are a prescription medicine and should be used only under the guidance of a qualified healthcare professional. Always follow your doctor's instructions regarding dosage and duration of treatment.

BARILUBE OINT SOP 3.5GM (Ocular Lubricant) – SHAIGAN PHARMA. PVT LTD

**Barilube Ophthalmic Ointment 3.5GM** **Product Description:** Barilube Ophthalmic Ointment 3.5GM is a sterile ocular lubricant specially formulated to provide long-lasting moisture and protection for dry, irritated, or sensitive eyes. It forms a smooth protective layer over the surface of the eye, helping to reduce friction, relieve discomfort, and maintain adequate lubrication. It is especially beneficial for individuals suffering from dry eye syndrome, exposure-related dryness, or eye irritation caused by environmental factors such as wind, dust, smoke, air conditioning, or prolonged screen use. Due to its thicker consistency, it provides extended lubrication and is often recommended for nighttime use or as advised by a healthcare professional. ### Uses: * Relieves symptoms of dry eye syndrome. * Lubricates and moisturizes dry, irritated, or burning eyes. * Provides temporary relief from eye discomfort caused by wind, dust, smoke, or prolonged digital screen exposure. * Protects the surface of the eye by forming a long-lasting lubricating film. * Helps reduce irritation following certain eye procedures or surgeries, as recommended by a healthcare professional. ### Benefits: * Provides long-lasting lubrication and comfort. * Reduces dryness, burning, itching, and foreign body sensation. * Protects the delicate surface of the eye from further irritation. * Helps maintain moisture and supports the natural tear film. * Sterile formulation suitable for regular use under medical guidance. ### Side Effects / Precautions: * For ophthalmic (eye) use only. * Temporary blurred vision may occur immediately after application due to the ointment's thick consistency. * Do not touch the tube tip to any surface, including the eye, to prevent contamination. * Remove contact lenses before application unless otherwise directed by your doctor. * Discontinue use and consult a healthcare professional if redness, pain, swelling, or irritation persists or worsens. * Store in a cool, dry place and keep the tube tightly closed after each use. * Keep out of the reach of children.

Berocca Tabs (Multivitamins + Minerals) – Bayer

Used For

Berocca Performance is a multivitamin and mineral supplement designed to support energy metabolism, reduce tiredness and fatigue, and support physical and mental performance. Its formulation includes B-complex vitamins, vitamin C, calcium, magnesium and zinc.

How It Works

The B-complex vitamins help the body release energy from food, while vitamin C, magnesium, calcium and zinc support various normal body functions. Together, these nutrients help support normal energy production and overall physical and mental performance.

Composition

The Berocca Performance formulation includes Vitamin B1, B2, B3, B5, B6, B7 (Biotin), B12, Folic Acid, Vitamin C, Calcium, Magnesium and Zinc. The exact quantities can vary by market and formulation; the Pakistan product page lists the Performance formula as containing these 12 vitamins/minerals.

Usage & Safety

Typically, one tablet is dissolved in a glass of water once daily, according to the product directions. Do not exceed the recommended daily intake.

Possible Side Effects: Some people may experience mild gastrointestinal discomfort or other intolerance. Stop use and seek medical advice if an allergic reaction occurs.

Indications

  • Nutritional supplementation
  • Tiredness and fatigue associated with inadequate nutrient intake
  • Support for energy metabolism
  • Support for physical and mental performance
  • Supplementation of B-complex vitamins and essential minerals

When Not to Use

Do not use if you are allergic or hypersensitive to any ingredient in the formulation. Avoid exceeding the recommended daily dose.

Precautions

People taking other vitamin/mineral supplements or medicines should check the combined nutrient intake to avoid excessive doses. Individuals with specific medical conditions should consult a healthcare professional before use.

Warnings

This product is intended as a nutritional supplement and should not be used as a substitute for a balanced diet. Keep out of reach of children.

Pregnancy

During pregnancy or breastfeeding, use should be discussed with a healthcare professional, particularly if other vitamin or mineral supplements are being taken.

Storage

Store in a cool, dry place, protected from moisture and direct sunlight. Keep the container tightly closed and out of reach of childre

Betaderm Cream 15g (Betamethasone Valerate) – Atco

Used For Eczema How it works Topical corticosteroids act as anti-inflammatory agents via multiple mechanisms to inhibit late phase allergic reactions including decreasing the density of mast cells, decreasing chemotaxis and activation of eosinophils, decreasing cytokine production by lymphocytes, monocytes, mast cells and eosinophils, and inhibiting the metabolism of arachidonic acid. Usage And Safety Dosage Adults & Children : Apply sparingly two or three times daily. OR As directed by your physician. Side Effects Common: may affect up to 1 in 10 people • local skin burning or pain • itchy skin Very rare: may affect up to 1 in 10,000 people : Use for a long period of time, or use under an airtight dressing, may cause the following symptoms: • increased weight • rounding of the face/moon face • obesity • thinning of your skin, this may cause stretch marks and it may also damage more easily • skin wrinkling Drug Interactions Ritonavir and itraconazole Indication It is used to help reduce the redness and itchiness of certain skin problems, such as eczema, psoriasis and dermatitis. Precautions Take care when applying to the eyelids to make sure it does not get into your eye as there may be a risk of developing glaucoma. Warnings Take care when applying to the face over a long period of time as it may cause skin thinning. If you are using this for a prolonged period of time there is a possibility you may develop a cataract (clouding of the eye's lens). Take care if you are using large quantities for a prolonged period or you are treating a large area of the body. This medicine may be absorbed through the skin and into your blood stream which can result in the following symptoms of hypercortisolism developing; stretch marks, the appearance of blood vessels under the surface of your skin, increased body hair growth, changes in skin colour, skin thinning, weight gain or rounding of the face (moon face). Additional Information Pregnancy category Always consult your physician before using any medicine. Storage (YES/NO) Store this medicine at room temperature, away from direct light and heat.

Betalol Ophthalmic Solution 0.5% 5ml (Timolol Maleate) – sante (private) limited

### How it Works Timolol Eye Drops belong to a group of medicines called **beta-blockers**. They help reduce the pressure inside the eye and are used to treat conditions such as **glaucoma** and **ocular hypertension (high pressure in the eye)**, including glaucoma that may develop after cataract surgery. ### Usage and Safety **Dosage** * **Adults:** Initially, instill **1 drop of 0.25% solution** into the affected eye(s) **twice daily**. If required, the strength may be increased to **0.5% solution twice daily**. * **Children:** Not recommended unless prescribed by a physician. ### Side Effects Common side effects may include: * Slow heart rate (bradycardia) * Irregular heartbeat (arrhythmia) * Atrioventricular (AV) block * Palpitations * Worsening of angina (chest pain) * Congestive heart failure * Swelling due to fluid retention (oedema) * Poor circulation or cold hands and feet * Ringing in the ears (tinnitus) * Dizziness * Eye irritation, burning, stinging, itching, tearing, or redness * Inflammation of the cornea or eyelids (keratitis, blepharitis) * Eye pain or blurred vision * Reduced corneal sensitivity * Dry eyes * Drooping eyelid (ptosis) * Double vision (diplopia) * Sensitivity to light (photophobia) ### Drug Interactions Timolol Eye Drops may interact with: * Adrenaline * Digoxin * Quinidine * Fluoxetine and Paroxetine * Calcium channel blockers (e.g., nifedipine, verapamil, diltiazem) * Clonidine or Reserpine * Other beta-blockers such as propranolol, atenolol, bisoprolol, metoprolol, carvedilol, nebivolol, labetalol, nadolol, pindolol, sotalol, acebutolol, celiprolol, and oxprenolol * Rauwolfia alkaloids ### Indication Used for the treatment of: * Glaucoma * Ocular hypertension (high pressure inside the eye) ### When Not to Use Do not use Timolol Eye Drops if you: * Are allergic to timolol, other beta-blockers (such as propranolol or betaxolol), or any of the ingredients. * Have or have had asthma, severe chronic obstructive pulmonary disease (COPD), or other serious breathing disorders. ### Precautions Consult your doctor before using Timolol Eye Drops if you have a history of: * Coronary heart disease * Chest pain (angina) * Heart failure * Breathing difficulties or other cardiovascular conditions ### Warning * Inform your doctor immediately if you experience an eye injury, undergo eye surgery, or develop an eye infection while using Timolol Eye Drops. * Timolol Eye Drops may cause dizziness, tiredness, blurred vision, drooping eyelids, or double vision. Avoid driving or operating machinery if these effects occur. * If you develop coughing, wheezing, difficulty breathing, or episodes of stopped breathing (apnoea), discontinue the medication immediately and contact your doctor as soon as possible. In some cases, a portable apnoea monitor may be recommended. ### Additional Information **Pregnancy** Always consult your physician before using this medicine during pregnancy or while breastfeeding. **Storage** Store this medicine at room temperature, away from direct heat, moisture, and sunlight. Keep the bottle tightly closed and out of the reach of children.

Betasalic Ointment 15g (Betamethasone Dipropionate , Salicylic Acid) – Atco

Used For Psoriasis How it works This medicine works by blocking certain chemicals in your body that cause swelling, itching, and irritation. It also removes the dead skin and promotes healing. Usage And Safety Dosage Adults & Children : Apply sparingly two or three times daily. OR As directed by your physician. Side Effects Skin irritation , Stinging , Change in color and texture of the skin , Redness of skin , Burning, itching, and irritation of the skin , Dry skin . Drug Interactions Ask your physician or pharmacist for dose adjustments. Indication It is used to treat skin conditions like psoriasis (red, itchy, and scaly patches on some areas of the body) and eczema (dry and itchy skin). When not to Use It should be avoided if you are allergic to it. Consult your doctor if you are pregnant, or are breastfeeding before using this medicine. Precautions Prolonged use of this medicine applied over a large area may lead to a toxic condition called salicylism marked by ringing in your ears, nausea, and vomiting. Appropriate corrective measures or another suitable alternative may be suggested by your doctor based on your clinical condition. Warnings It is recommended for use on the skin only. Avoid contact with your mouth, eyes, nose, cuts, or open wounds. Wash immediately with water in case of accidental contact. Do not use if there is an infection or sore present in the area to be treated. Long-term use should be done with caution as it may cause thinning of skin at the site of application or cause stretch marks. Additional Information Pregnancy category Always consult your physician before using any medicine. Storage (YES/NO) Store this medicine at room temperature, away from direct light and heat.

BFL Forte Eye Drops, 5ml (Fluorometholone) – Barrett Hodgson

BFL FORTE Eye Drops contain Fluorometholone 0.25% (2.5 mg/ml), a corticosteroid ophthalmic suspension used for the short-term treatment of steroid-responsive inflammatory conditions of the eye. It helps relieve redness, swelling, irritation, burning, and discomfort caused by allergies, chemical exposure, heat, radiation, minor eye injuries, or following certain eye procedures.

By reducing inflammation directly at the affected site, BFL FORTE provides targeted relief while helping protect delicate eye tissues from further inflammatory damage. This medicine should only be used under the supervision of an eye specialist.


Key Benefits

  • Effectively reduces eye inflammation and irritation.
  • Relieves redness, burning, itching, and swelling.
  • Helps manage inflammation caused by allergies and environmental irritants.
  • Supports recovery after minor eye injuries and certain ophthalmic procedures.
  • Delivers targeted anti-inflammatory action directly to the eye.
  • Provides rapid symptomatic relief from steroid-responsive eye conditions.

Composition

Each 1 ml contains:

  • Fluorometholone BP2.5 mg (0.25% w/v)

Indications

BFL FORTE Eye Drops are indicated for the treatment of steroid-responsive inflammatory eye conditions, including:

  • Allergic conjunctivitis
  • Inflammation of the conjunctiva and cornea
  • Eye irritation caused by chemicals, heat, or radiation
  • Inflammation due to minor eye injuries or foreign body irritation
  • Post-operative ocular inflammation (as prescribed)
  • Other non-infectious inflammatory disorders of the anterior segment of the eye

How It Works

Fluorometholone is a corticosteroid that works by suppressing the release of inflammatory substances responsible for redness, swelling, itching, and pain. It helps reduce inflammation within the eye, providing relief from discomfort while supporting the healing process.


Directions for Use

  • Use only as prescribed by your doctor.
  • Shake the bottle well before each use.
  • Wash your hands before applying the drops.
  • Instill the prescribed number of drops into the affected eye(s).
  • Avoid touching the dropper tip to the eye or any surface to prevent contamination.
  • If using more than one eye medication, wait at least 5–10 minutes between applications.

Precautions

  • For ophthalmic use only.
  • Do not use if you have untreated viral, fungal, or certain bacterial eye infections unless advised by your doctor.
  • Prolonged use may increase intraocular pressure and the risk of glaucoma or cataract formation.
  • Remove contact lenses before using the drops unless your doctor advises otherwise.
  • Inform your healthcare provider if you are pregnant, breastfeeding, or have a history of glaucoma or eye infections.

Possible Side Effects

Some people may experience:

  • Temporary burning or stinging
  • Mild eye irritation
  • Blurred vision immediately after application
  • Increased intraocular pressure with prolonged use
  • Delayed healing of eye tissues
  • Secondary eye infections with long-term use

Seek medical attention immediately if you experience severe eye pain, vision changes, persistent redness, or signs of an allergic reaction.


Storage Instructions

  • Store below 25°C in a cool, dry place.
  • Protect from direct sunlight.
  • Keep the bottle tightly closed when not in use.
  • Keep out of the reach of children.
  • Do not use after the expiry date.

Blink Fresh Eye Drops 10ml ( Polyvinyl Alcohol , Povidone) – sante (private) limited

# **Blink Fresh Ophthalmic Solution** ## **Used For** Blink Fresh Ophthalmic Solution is specially formulated to provide long-lasting lubrication and relief for **dry, irritated, and tired eyes**. It helps restore moisture to the ocular surface, providing comfort throughout the day. --- ## **How It Works** Blink Fresh contains **Polyvinyl Alcohol** and **Povidone**, two effective ocular lubricants that mimic natural tears. These ingredients stabilize the tear film, reduce friction on the eye surface, and provide soothing relief from dryness and irritation. Their hydrophilic properties help retain moisture, ensuring prolonged eye lubrication. --- ## **Usage & Safety** ### **Dosage** **Adults:** Instill **1–2 drops** into the affected eye(s) as needed, or as directed by your physician. --- ## **Possible Side Effects** Blink Fresh is generally well tolerated. However, mild and temporary eye irritation or discomfort may occur in some individuals. Consult your physician or pharmacist if you experience any unexpected side effects. --- ## **Drug Interactions** No significant drug interactions are commonly reported. However, inform your physician or pharmacist about all medicines you are currently using, including other ophthalmic products. --- ## **Indications** * Lubrication of dry eyes * Relief from burning, irritation, and discomfort caused by insufficient tear production * Temporary relief from environmental eye dryness --- ## **Contraindications** Do not use this product if you are allergic or hypersensitive to **Polyvinyl Alcohol, Povidone**, or any other ingredient in the formulation. --- ## **Precautions** * Do not use the solution if it becomes cloudy, discolored, or contains visible particles. * Remove contact lenses before application unless otherwise advised by your eye care professional. * Avoid touching the dropper tip to any surface to prevent contamination. --- ## **Warnings** * Discontinue use and consult your physician immediately if you experience eye pain, vision changes, persistent redness or irritation, worsening symptoms, or if symptoms continue for more than **72 hours**. * For **ophthalmic use only**. Avoid contact with the nose, mouth, or other body surfaces. In case of accidental contact, rinse thoroughly with clean water. * To maintain sterility, do not touch the dropper tip with your fingers or allow it to come into contact with any surface. Always replace the cap tightly after each use. --- ## **Additional Information** ### **Pregnancy & Breastfeeding** If you are pregnant, planning to become pregnant, or breastfeeding, consult your physician before using this product. --- ## **Storage Instructions** Store at **room temperature** in a cool, dry place, away from direct sunlight and excessive heat. Keep the bottle tightly closed and out of the reach of children.

Blinkol Eye Drops 15ml (Polyethylene Glycol, Propylene Glycol) – remington pharmaceutical

Used For Dry Eyes How it works It is a medicine that consists of Polyethylene glycol and Propylene glycol. It is a lubricating agent used for the temporary relief of symptoms such as burning, irritation, stinging, grittiness, foreign body sensation, etc., caused due to dryness of the eyes or other environmental factors. Usage And Safety Dosage Adults : 1-2 drops as required. OR As directed by your physician. Side Effects Redness of the eye , Blurred vision , Eye pain , Changes in vision. Drug Interactions Ask your physician or pharmacist for any drug interaction. Indication It is used for dry eyes. When not to Use Avoid using Eye Drops if you are allergic to it. Contact your doctor immediately if you notice any symptoms such as skin rashes, itching/swelling, dizziness, breathing difficulty, etc. Warnings If you experience any symptoms such as eye pain, changes in vision, continued redness or irritation, worsening of the condition or persistence of symptoms for more than 72 hours after using Lubricant Eye Drops, contact your doctor for further consultation. Additional Information Pregnancy category Always consult your physician before using any medicine. Storage (YES/NO) Store this medicine at room temperature, away from direct light and heat.

Bofalgan 1G/100ml Infusion (Paracetamol) – Bosch Pharma

Bofalgan® 1G/100ml Infusion

Bofalgan® 1G/100ml Infusion contains Paracetamol 1g and is an intravenous medicine used for the short-term treatment of pain and fever, particularly when oral administration is not suitable. It provides systemic pain relief and helps reduce elevated body temperature.

Used For

  • Short-term relief of moderate pain
  • Reduction of fever
  • Pain and fever management when oral medication cannot be used

How It Works

Paracetamol works primarily by reducing the production of prostaglandins involved in pain and temperature regulation. When administered intravenously, it provides a rapid and controlled delivery of the medicine into the bloodstream.

Usage & Safety

Bofalgan® Infusion should be administered intravenously by a qualified healthcare professional. The dose and duration depend on the patient's age, body weight, medical condition, and response to treatment. Excessive doses of paracetamol can cause serious liver damage. Patients should avoid taking other medicines containing paracetamol unless advised by a healthcare professional.

Indications

  • Fever
  • Acute pain
  • Short-term pain management when oral treatment is unsuitable

When Not to Use

It should not be used in patients with severe liver impairment or a known allergy to paracetamol or any of its ingredients.

Precautions

Use with caution in patients with liver or kidney problems, chronic alcohol use, malnutrition, or dehydration. Always inform the healthcare professional about other medicines being taken.

Warnings

Do not exceed the recommended dose. Accidental overdose may result in severe liver injury and requires immediate medical attention.

Pregnancy

Use during pregnancy only when considered necessary and under the supervision of a healthcare professional.

Storage

Store according to the manufacturer's recommended conditions. Keep away from excessive heat, direct sunlight, and out of the reach of children. Manufacturer: Bosch Pharmaceuticals (Pvt.) Ltd.

Bosmon 62.5mg Tab ( Bosentan Monohydrate ) Hilton

Generics Bosentan Monohydrate Used For Hypertension How it works Bosentan is a dual endothelin receptor antagonist with affinity for both ETA and ETB receptors. Bosentan decreases both pulmonary and systemic vascular resistance, resulting in increased cardiac output without increasing heart rate. The neurohormone endothelin is a potent vasoconstrictor with the ability to promote fibrosis, cell proliferation, and tissue remodeling. Endothelin concentrations in plasma and tissues are increased in a number of cardiovascular disorders, including pulmonary hypertension, suggesting a pathological role for endothelin in these diseases. In pulmonary arterial hypertension, endothelin plasma concentrations strongly correlate with poor prognosis . Bosmon Tablets Usage And Safety Dosage Bosentan Monohydrate Side Effects Flushed appearance or redness of skin ; Hypersensitivity reactions (including skin inflammation, itching and rash) ; Gastrooesophageal reflux disease (acid reflux) ; Diarrhoea ; Stuffy or blocked nose ; Syncope (fainting) ; Palpitations (fast or irregular heart beats) ; Low blood pressure . Drug Interactions Warfarin , Simvastatin and Other Statins , Glyburide , Ketoconazole , Cyclosporine A , Tacrolimus and Sirolimus , Sildenafil , Tadalafil , Rifampicin , Epoprostenol , Antiretroviral Agents: Lopinavir + Ritonavir . Indication It is indicated for the treatment of pulmonary arterial hypertension in patients with WHO functional class III or IV primary pulmonary hypertension, or pulmonary hypertension secondary to scleroderma or congenital heart disease or human immunodeficiency virus in patients who did not respond adequately to conventional therapy . When not to Use It is contraindicated in patients: Who are hypersensitive to bosentan or to any excipient in the formulation ; Who are pregnant, or of childbearing potential unless adequate contraceptive measures are taken. Fetal malformations were reported in animals . Bosmon Tablets Precautions Precaution Cases of pulmonary edema have been reported with vasodilators (mainly prostacyclins) when used in patients with pulmonary veno-occlusive disease. Consequently, should signs of pulmonary edema occur when Bosentan is administered in patients with Pulmonary arterial hypertension (PAH) , the possibility of associated veno-occlusive disease should be considered. Bosmon Tablets Warnings Warning 1 The efficacy of bosentan has not been established in patients with severe Pulmonary arterial hypertension (PAH). Transfer to a therapy that is recommended at the severe stage of the disease (e.g. epoprostenol) should be considered if the clinical condition deteriorates . Warning 2 Bosentan should only be initiated if the systemic systolic blood pressure is higher than 85 mmHg. Warning 3 Bosentan has not been shown to have a beneficial effect on the healing of existing digital ulcers. Bosmon Tablets Additional Information Pregnancy category Always consult your physician before using any medicine. Storage (YES/NO) Store this medicine at room temperature, away from direct light and heat.