Secnidal Forte ( Secnidazole ) Sanofi
This medication is used to treat a certain type of vaginal infection (bacterial vaginosis) in women.Secnidazole is also used to treat a certain common sexually transmitted infection (trichomoniasis). If you are taking this medication for trichomoniasis, your sexual partner(s) should be treated at the same time.Secnidazole is an antibiotic that works by stopping the growth of bacteria. This antibiotic treats only bacterial infections. It will not work for viral infections (such as common cold, flu). Using any antibiotic when it is not needed can cause it to not work for future infections.
How to use Secnidazole Granules Delayed Release For Suspension In A Packet (Granules Susp Packet)
Read the Patient Information Leaflet and the Instructions for Use if available from your pharmacist before you start taking secnidazole and each time you get a refill. If you have any questions, ask your doctor or pharmacist.
Take this medication by mouth as directed by your doctor. This medication is taken as a single dose.
Open the packet and pour its contents onto applesauce, yogurt, or pudding. Eat all of the mixture within 30 minutes without chewing or crunching the granules. Do not prepare a supply in advance. You may drink a glass of water afterward to help with swallowing the medication.
Avoid drinking alcoholic beverages and preparations that contain ethanol or propylene glycol during treatment and for at least 2 days after completing treatment. Doing so may make side effects worse.
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Kenacomb Cream – GSK
KENACOMB combines the potent corticosteroid triamcinolone acetonide with the antifungal antibiotic nystatin and the wide spectrum antibacterial activity of neomycin and gramicidin.
KENACOMB reduces inflammation, relieves pruritis and combats or prevents monilial and bacterial infections.
Pharmacokinetics
The extent of percutaneous absorption of topical corticosteroids is determined by many factors including the vehicle, the integrity of the epidermal barrier, and the use of occlusive dressings.
Topical corticosteroids can be absorbed from normal intact skin, inflammation and/or other disease processes in the skin increase percutaneous absorption.
Nystatin and gramicidin are not absorbed from intact skin or mucous membranes.
Neomycin can be absorbed through inflamed skin. Once absorbed, it is rapidly excreted unchanged through the kidneys. The half-life is approximately 2 to 3 hours.
Microbiology
Nystatin acts by binding to sterols in the cell membrane of susceptible species resulting in a change in membrane permeability and the subsequent leakage of intracellular components.
Nystatin exhibits no activity against bacteria, protozoa, or viruses.
Neomycin exerts its bacterial activity against a number of gram-negative organisms by inhibiting protein synthesis. It is not active against Pseudomonas aeruginosa, and resistant strains of gram-negative bacteria may develop.
Gramicidin exerts its antibacterial activity against many gram-positive organisms by altering cell membrane permeability.
INDICATIONS
KENACOMB is indicated for use in corticosteroid responsive dermatoses complicated or threatened by secondary monilial and/or bacterial infections, such as:
Atopic dermatitis
Seborrhoeic dermatitis
Lichen simplex chronicus
Psoriasis (particularly of the face and body folds)
Allergic contact dermatitis
KENACOMB CREAM permits use in moist intertrigenous areas.
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