Nilstat Drops (Nystatin) – Wyeth
Nilstat is used to treat fungal infections of the mouth. Nystatin is an antifungal that works by stopping the growth of fungus.
Nystatin suspension should not be used to treat fungal infections of the blood.
How to use Nilstat Suspension
Shake well before using, and use the provided medication dropper to carefully measure out the dose. Unless your doctor instructs you otherwise, use as follows: Place half of the dose in one side of the mouth. Swish it around the mouth, gargle, and swallow or spit out as directed. Keep the liquid in your mouth for as long as possible. Then repeat with the remaining half of the dose in the other side of the mouth. Avoid eating for 5-10 minutes after using this medication.
Use this medication 4 times a day or as directed by your doctor. It may take from several days to several months to complete treatment. Use this medication regularly in order to get the most benefit from it. Remember to use it at the same times each day. Dosage is based on your medical condition and response to therapy.
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Kenacomb Cream – GSK
KENACOMB combines the potent corticosteroid triamcinolone acetonide with the antifungal antibiotic nystatin and the wide spectrum antibacterial activity of neomycin and gramicidin.
KENACOMB reduces inflammation, relieves pruritis and combats or prevents monilial and bacterial infections.
Pharmacokinetics
The extent of percutaneous absorption of topical corticosteroids is determined by many factors including the vehicle, the integrity of the epidermal barrier, and the use of occlusive dressings.
Topical corticosteroids can be absorbed from normal intact skin, inflammation and/or other disease processes in the skin increase percutaneous absorption.
Nystatin and gramicidin are not absorbed from intact skin or mucous membranes.
Neomycin can be absorbed through inflamed skin. Once absorbed, it is rapidly excreted unchanged through the kidneys. The half-life is approximately 2 to 3 hours.
Microbiology
Nystatin acts by binding to sterols in the cell membrane of susceptible species resulting in a change in membrane permeability and the subsequent leakage of intracellular components.
Nystatin exhibits no activity against bacteria, protozoa, or viruses.
Neomycin exerts its bacterial activity against a number of gram-negative organisms by inhibiting protein synthesis. It is not active against Pseudomonas aeruginosa, and resistant strains of gram-negative bacteria may develop.
Gramicidin exerts its antibacterial activity against many gram-positive organisms by altering cell membrane permeability.
INDICATIONS
KENACOMB is indicated for use in corticosteroid responsive dermatoses complicated or threatened by secondary monilial and/or bacterial infections, such as:
Atopic dermatitis
Seborrhoeic dermatitis
Lichen simplex chronicus
Psoriasis (particularly of the face and body folds)
Allergic contact dermatitis
KENACOMB CREAM permits use in moist intertrigenous areas.
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