Depo Medrol 80mg Injection – (Methylprednisolone Acetate)
Depo Medrol 80mg Injection is an anti-inflammatory medication. It is used to treat various conditions characterised by pain and swelling, including rheumatoid arthritis, osteoarthritis, ulcerative colitis, and lupus. Depo Medrol 80mg contains the active ingredient methylprednisolone, which belongs to the class of drugs called glucocorticoids.
How effective is Depo Medrol 80mg?
Depo Medrol 80mg Injection is very effective for the treatment of various painful and inflammatory conditions of the joints, blood, eyes, kidney, thyroid, lungs and intestines. Its use is indicated in the treatment of arthritis, bronchial asthma, systemic lupus erythematosus, Crohn’s disease, certain cancers, severe allergic reactions, bursitis, keloids, TB meningitis, psoriasis, etc. Depo Medrol 80mg works by decreasing the activity of the immune system and inhibiting the production of inflammatory chemicals. This provides relief to the inflammation, pain, swelling and allergic reactions.
For the treatment of dermatological conditions in adults, the usual dose is 1-3 ml given through the intramuscular route only once.
For the treatment of rheumatoid arthritis and other collagen diseases in adults, the usual dose is 1-3 ml given through the intramuscular route once per week.
The dosage depends upon the condition and its severity. It must be individualised.
If you skip a dose by any chance, take it as soon as you remember. Skip the already missed dose if it’s almost time for the next one. Do not double the dose.
What are the side-effects and other warnings when taking Depo Medrol 80mg?
Some common and uncommon side-effects when taking Depo Medrol 80mg include:
Dizziness
Difficulty sleeping
Acne
Nausea
Vomiting
Changes in appetite
Increased sweating
If you experience any side-effects that persist or worsen or any unusual symptoms, contact your doctor immediately.
Notify your doctor about any prescription/non-prescription drugs you may be taking.
If you are pregnant, might become pregnant, or think you may be pregnant or breast-feeding or planning to breast-feed, notify your doctor or a pharmacist at emeds Pharmacy before using this drug.
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Kenacomb Cream – GSK
KENACOMB combines the potent corticosteroid triamcinolone acetonide with the antifungal antibiotic nystatin and the wide spectrum antibacterial activity of neomycin and gramicidin.
KENACOMB reduces inflammation, relieves pruritis and combats or prevents monilial and bacterial infections.
Pharmacokinetics
The extent of percutaneous absorption of topical corticosteroids is determined by many factors including the vehicle, the integrity of the epidermal barrier, and the use of occlusive dressings.
Topical corticosteroids can be absorbed from normal intact skin, inflammation and/or other disease processes in the skin increase percutaneous absorption.
Nystatin and gramicidin are not absorbed from intact skin or mucous membranes.
Neomycin can be absorbed through inflamed skin. Once absorbed, it is rapidly excreted unchanged through the kidneys. The half-life is approximately 2 to 3 hours.
Microbiology
Nystatin acts by binding to sterols in the cell membrane of susceptible species resulting in a change in membrane permeability and the subsequent leakage of intracellular components.
Nystatin exhibits no activity against bacteria, protozoa, or viruses.
Neomycin exerts its bacterial activity against a number of gram-negative organisms by inhibiting protein synthesis. It is not active against Pseudomonas aeruginosa, and resistant strains of gram-negative bacteria may develop.
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INDICATIONS
KENACOMB is indicated for use in corticosteroid responsive dermatoses complicated or threatened by secondary monilial and/or bacterial infections, such as:
Atopic dermatitis
Seborrhoeic dermatitis
Lichen simplex chronicus
Psoriasis (particularly of the face and body folds)
Allergic contact dermatitis
KENACOMB CREAM permits use in moist intertrigenous areas.
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