Amgydex Ointment ( Tobramycin Dexamethasone ) KOBEC
Used For Eye Infection
The efficacy of corticosteroids for the treatment of inflammatory conditions of the eye is well established. Corticosteroids achieve their anti-inflammatory effects through suppression of vascular endothelial cell adhesion molecules, cyclooxygenase I or II, and cytokine expression. This action culminates in a reduced expression of pro-inflammatory mediators and the suppression of adhesion of circulating leukocytes to the vascular endothelium, thereby preventing their migration into inflamed ocular tissue. Dexamethasone has marked anti-inflammatory activity with reduced mineralocorticoid activity compared with some other steroids, and is one of the most potent anti-inflammatory agents. Tobramycin is a potent, broad-spectrum, rapidly bactericidal aminoglycoside antibiotic. It exerts its primary effect on bacterial cells by inhibiting polypeptide assembly and synthesis on the ribosome. Tobramycin in this combination provides antibacterial protection against susceptible bacteria.
Amgydex Eye Usage And Safety
Dosage
Tobramycin , Dexamethasone
Side Effects
• Eye irritation, itchiness or feeling of having something in the eye • eye pain • inflammation of the cornea (clear front portion of your eye) (punctate keratitis) • swollen or itchy eyelids • eye redness • increased tearing or dry eyes • blurred vision • drooping eyelid • dilated pupil • another (secondary) eye infection • formation of cataracts • raised pressure in the eye which may lead to headaches and disturbances of vision • slowed healing of the cornea • changes to sensations of taste • headache • nausea • stomach discomfort.
Drug Interactions
NSAID , CYP3A4 inhibitors , anticholinergics , other phosphate containing ocular preps .
Indication
It is used to treat inflammation, corneal injury and bacterial infections in the external part of the eye.
When not to Use
Do not use if you have an allergy to: •Tobramycin or any other aminoglycoside antibiotics • Dexamethasone or any other corticosteroids • Any of the ingredients in the list.
Amgydex Eye Precautions
Precaution
Do not use Tobramycin & Dexamethasone for longer than your doctor tells you. If you use Tobramycin + Dexamethasone Eye ointment for longer than your doctor or pharmacist tells you, the chance of side effects may increase.
Amgydex Eye Warnings
Warning 1
It is not for use in children. The safety and effectiveness in children has not been established.
Warning 2
Do not use Eye ointment if you have an eye infection including infections caused by a virus, fungus or a parasite.
Warning 3
The preservative in Eye ointment is benzalkonium chloride, may be deposited in soft contact lenses. You can put your soft contact lenses back into your eyes 15 minutes after you have used Tobramycin Eye ointment.
Amgydex Eye Additional Information
Pregnancy category
Always consult your physician before using any medicine.
Store this medicine at room temperature, away from direct light and heat.
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Pharmacokinetics
The extent of percutaneous absorption of topical corticosteroids is determined by many factors including the vehicle, the integrity of the epidermal barrier, and the use of occlusive dressings.
Topical corticosteroids can be absorbed from normal intact skin, inflammation and/or other disease processes in the skin increase percutaneous absorption.
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Microbiology
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Neomycin exerts its bacterial activity against a number of gram-negative organisms by inhibiting protein synthesis. It is not active against Pseudomonas aeruginosa, and resistant strains of gram-negative bacteria may develop.
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INDICATIONS
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Psoriasis (particularly of the face and body folds)
Allergic contact dermatitis
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