Used For Eye Infection The efficacy of corticosteroids for the treatment of inflammatory conditions of the eye is well established. Corticosteroids achieve their anti-inflammatory effects through suppression of vascular endothelial cell adhesion molecules, cyclooxygenase I or II, and cytokine expression. This action culminates in a reduced expression of pro-inflammatory mediators and the suppression of adhesion of circulating leukocytes to the vascular endothelium, thereby preventing their migration into inflamed ocular tissue. Dexamethasone has marked anti-inflammatory activity with reduced mineralocorticoid activity compared with some other steroids, and is one of the most potent anti-inflammatory agents. Tobramycin is a potent, broad-spectrum, rapidly bactericidal aminoglycoside antibiotic. It exerts its primary effect on bacterial cells by inhibiting polypeptide assembly and synthesis on the ribosome. Tobramycin in this combination provides antibacterial protection against susceptible bacteria. Amgydex Eye Usage And Safety Dosage Tobramycin , Dexamethasone Side Effects • Eye irritation, itchiness or feeling of having something in the eye • eye pain • inflammation of the cornea (clear front portion of your eye) (punctate keratitis) • swollen or itchy eyelids • eye redness • increased tearing or dry eyes • blurred vision • drooping eyelid • dilated pupil • another (secondary) eye infection • formation of cataracts • raised pressure in the eye which may lead to headaches and disturbances of vision • slowed healing of the cornea • changes to sensations of taste • headache • nausea • stomach discomfort. Drug Interactions NSAID , CYP3A4 inhibitors , anticholinergics , other phosphate containing ocular preps . Indication It is used to treat inflammation, corneal injury and bacterial infections in the external part of the eye. When not to Use Do not use if you have an allergy to: •Tobramycin or any other aminoglycoside antibiotics • Dexamethasone or any other corticosteroids • Any of the ingredients in the list. Amgydex Eye Precautions Precaution Do not use Tobramycin & Dexamethasone for longer than your doctor tells you. If you use Tobramycin + Dexamethasone Eye ointment for longer than your doctor or pharmacist tells you, the chance of side effects may increase. Amgydex Eye Warnings Warning 1 It is not for use in children. The safety and effectiveness in children has not been established. Warning 2 Do not use Eye ointment if you have an eye infection including infections caused by a virus, fungus or a parasite. Warning 3 The preservative in Eye ointment is benzalkonium chloride, may be deposited in soft contact lenses. You can put your soft contact lenses back into your eyes 15 minutes after you have used Tobramycin Eye ointment. Amgydex Eye Additional Information Pregnancy category Always consult your physician before using any medicine. Store this medicine at room temperature, away from direct light and heat.