Dirogest tablet (ZAFA) helps treats disorders related to the female reproductive cycle, infertility, irregular menses and uterine bleeding. Determine the cause of abnormal uterine bleeding before you begin Dirogest treatment. In the early stages of treatment, the medicine may result in breakthrough bleeding and spotting. What is it used for? Abdominal pain and bleeding during preganancy (threatened miscarriage) or history of miscarriages (habitual abortion) Abdominal pain associated with menstrual periods (dysmenorrhoea) Absence of menstrual periods when taking oestrogens Endometriosis Female infertility Irregular menstrual bleeding when taking oestrogens Irregular menstrual cycles Premenstrual syndrome How does it work? Dirogest tablets contain the active ingredient dydrogesterone, which is a synthetic hormone similar to the naturally occurring sex hormone, progesterone. It is used in a wide range of menstrual disorders that are thought to result from a lack of progesterone in the body. In women, progesterone is responsible for the development of a healthy womb lining (endometrium) that is necessary for pregnancy. The body produces progesterone at certain times of the menstrual cycle, causing the womb lining to flourish. If a fertilized egg does not attach to the womb lining by the end of the monthly menstrual cycle, the levels of progesterone in the body decrease. This causes the body to shed the womb lining (a menstrual ‘period’). If a fertilized egg successfully attaches to the womb lining by the end of the monthly cycle, progesterone levels in the body remain high. This helps maintain a healthy womb lining for the ongoing pregnancy