Bacterial Infection How it works Levofloxacin is a synthetic broad spectrum anti-bacterial agent. Chemically it is a chiral fluorinated carboxyquinolone. It acts by inhibiting DNA-gyrase. It is bactericidal and has activity against many gram +ve, gram –ve and Anaerobic bacteria. Usage And Safety Dosage Levofloxacin Side Effects Itching and rash. Nausea, diarrhoea, loss of appetite, abdominal pain, dyspepsia, Headache, vertigo, dizziness, sleeping problems, paraesthesia e.g. like tingling in the hands, restlessness, anxiety, and confusions, drop of blood pressure, tendon pain, tendon rupture (Achilles Tendon). Drug Interactions Concurrent Antacids, Sucralfate, Metal Cations, Multivitamins , NSAID’s. Indication It is used to treat •Acute & Chronic Sinusitis • Community acquired pneumonia • Complicated Skin & Soft tissue Infections • Acute Pyelonephritis • Acute & Chronic Bronchitis • Nosocomial pneumonia • Complicated & Uncomplicated UTI • Typhoid & paratyphoid fever. When not to Use Levofloxacin is contraindicated in cases of hypersensitivity to the active ingredient or any other quinolone. Precautions Precaution Serious and occasionally hypersensitivity and/or anaphylactic reactions have been reported in patients receiving therapy with quinolone, including Levofloxacin and should be discontinued immediately. Warnings Warning 1 Excessive exposure to sunlight should be avoided. Therapy should be discontinued if skin eruptions occurs. Warning 2 Although Levofloxacin is more soluble than other quinolones, adequate hydration of patients receiving Levofloxacin should be maintained to prevent the formation of highly concentrated urine. Warning 3 Levofloxacin should be administered with caution in the presence of renal insufficiency. Additional Information Pregnancy category Always consult your physician before using any medicine. Storage (YES/NO) Store this medicine at room temperature, away from direct light and heat.