Used For Letrozole 2.5mg Tablets are primarily used for the treatment of hormone receptor-positive breast cancer in postmenopausal women. They may also be prescribed before surgery or after other hormone therapies as recommended by an oncologist. How It Works Letrozole belongs to the class of medicines known as aromatase inhibitors. It works by blocking the aromatase enzyme responsible for producing estrogen in the body. Lower estrogen levels help slow or stop the growth of hormone-sensitive breast cancer cells while having minimal effects on other hormone-producing glands. Usage & Safety Dosage The usual adult dose is one 2.5mg tablet once daily, with or without food. Take the medicine at the same time each day for the best results. Always use it exactly as prescribed by your doctor. Possible Side Effects Some people may experience: Hot flushes Headache Dizziness Fatigue Joint or muscle pain Nausea Constipation or diarrhea Increased sweating Weight changes Hair thinning High cholesterol Osteoporosis or reduced bone density Swelling of the hands or feet Seek immediate medical attention if you develop chest pain, difficulty breathing, severe allergic reactions, blood clots, or signs of liver problems. Drug Interactions Tell your healthcare provider if you are taking: Tamoxifen Warfarin Cimetidine Other hormonal therapies Prescription, non-prescription, or herbal medicines Indications Letrozole is commonly prescribed for: Early-stage hormone receptor-positive breast cancer Advanced or metastatic breast cancer Adjuvant treatment after surgery Extended therapy following Tamoxifen treatment Neoadjuvant therapy before surgery in selected patients When Not to Use Do not use Letrozole if: You are allergic to Letrozole or any of its ingredients. You are pregnant or breastfeeding. You have not yet reached menopause unless specifically advised by your doctor. Precautions Inform your doctor before using Letrozole if you have: Osteoporosis or a history of bone fractures Liver disease Kidney impairment High cholesterol Heart disease Regular monitoring of bone health and cholesterol levels may be required during treatment. Warning Long-term use may reduce bone mineral density and increase the risk of osteoporosis or fractures. Your doctor may recommend regular bone density tests. Blood cholesterol levels may increase during treatment. Periodic lipid profile monitoring is recommended. Patients with severe liver impairment may require dose adjustments and close medical supervision. Additional Information Pregnancy Letrozole should not be used during pregnancy or while breastfeeding. Always consult your healthcare provider before taking this medicine. Storage Store below 30°C in a cool, dry place away from direct sunlight, moisture, and heat. Keep out of the reach of children.