Augmentin BD 457 ( Co-Amoxiclav ) GSK
Generics : Co-Amoxiclav
Used For
Bacterial InfectionHow it works
The beta-lactamase inhibitory action of clavulanate extends the spectrum of amoxicillin to embrace a wider range of organisms, including many resistant to other beta-lactam antibiotics.Usage And Safety
Dosage
Oral : Suspension 156.25 mg . Children : Under 3 months , not recommended , 3-9 months , 2.5ml half-strength , 9months-2yr , 5ml half strength . 2-6yr , 5ml. All three Times daily up to 14 days. Tablets : Mild - Moderate infections: 375mg three times a day or One 625 mg tablet every 12 hours. Severe infections : One 1 g tablet every 12 hours. Always take this medicine exactly as your doctor has told you. Dosage depends on the age and renal function of the patient and the severity of the infection. INJ : Adults : 1.2gm by IV inj or intermittent infusion eight or six hourly . Treat up to 14 days then review . Children : Up to 3 month , 30mg/kg every twelve hr in premature and full term infants during the perinatal period , increasing to eight hr thereafter ; 3 mnth-12yr, 30mg/kg eight or six hourly . All by IV inj or intermittent infusion for up to 14 days then revise . OR As directed by your physician.Side Effects
Mucocutaneous candidiasis , Reversible leukopenia (including neutropenia) and thrombocytopenia , Angioneurotic oedema, anaphylaxis, serum sickness-like syndrome, hypersensitivity vasculitis , Dizziness, headache , Diarrhoea , Nausea, vomiting , Indigestion .Drug Interactions
Mycophenolate mofetil , Probenecid , Oral contraceptives , acenocoumarol or warfarin .Indication
It is an antibiotic agent with a notably broad spectrum of activity against the commonly occurring bacterial pathogens .When not to Use
It is contraindicated in patients with a history of hypersensitivity to betalactams, e.g. penicillins and cephalosporins.Precautions
Before initiating therapy with Co-Amoxiclav, careful enquiry should be made concerning previous hypersensitivity reactions to penicillins, cephalosporins, or other allergens.
Warnings
- ) Serious and occasionally fatal hypersensitivity reactions (including anaphylactoid and severe cutaneous adverse reactions) have been reported in patients on penicillin therapy. These reactions are more likely to occur in individuals with a history of penicillin hypersensitivity.
2. ) Prolonged use may also occasionally result in overgrowth of non-susceptible organisms.
3. ) In patients with renal impairment, Co-Amoxiclav dosage should be adjusted as recommended.
Additional Information
Pregnancy category
Always consult your physician before using any medicine.Storage
Store this medicine at room temperature, away from direct light and heat.
Calamox 1000mg (Co-amoxiclav) – One Health
**Calamox 1000mg Tablets** are a combination antibiotic formulated to treat a variety of bacterial infections. It contains **Amoxicillin** and **Clavulanic Acid**, which work together to effectively eliminate infection-causing bacteria while helping to overcome bacterial resistance mechanisms. It is commonly prescribed for infections affecting the respiratory tract, urinary tract, skin, and soft tissues.
### Key Benefits
✓ Effective in the treatment of a broad range of bacterial infections.
✓ Clavulanic Acid enhances the antibacterial activity of Amoxicillin by protecting it from bacterial resistance.
✓ Broad-spectrum antibiotic action against multiple bacterial strains.
✓ Helps provide prompt relief from infection-related symptoms when used as directed.
### Who Can Use It?
✓ Adults and children, as prescribed by a healthcare professional, for bacterial infections involving the respiratory system, urinary tract, skin, and soft tissues.
✓ Not recommended for patients with known hypersensitivity to penicillin, cephalosporin antibiotics, or any of its ingredients.
### Possible Side Effects
**Common Side Effects:**
✓ Nausea
✓ Diarrhea
✓ Mild abdominal discomfort
✓ Skin rash
**Rare but Serious Side Effects:**
✓ Severe allergic reactions
✓ Liver function disturbances
✓ Antibiotic-associated colitis
### Warnings & Precautions
✓ This medicine is not effective against viral illnesses such as the common cold or influenza.
✓ Use with caution in patients with impaired liver or kidney function.
✓ Complete the full prescribed course even if symptoms improve, to help prevent bacterial resistance and recurrence of infection.
### Dosage
Use strictly according to your physician’s instructions. Dosage may vary depending on the type and severity of the infection, as well as the patient's clinical condition.
### Additional Information
**Prescription Status:** Prescription Only Medicine (POM)
**Generic Name:** Amoxicillin + Clavulanic Acid
**Pregnancy & Breastfeeding:** Consult your healthcare provider before use during pregnancy or while breastfeeding.
**Contraindications:** Do not use if you have a history of allergy to penicillins, cephalosporins, or severe hypersensitivity reactions to similar antibiotics.
### Storage Instructions
Store in a cool, dry place at room temperature. Protect from direct sunlight, moisture, and excessive heat. Keep out of the reach of children.
Clamentin Ds (312.50Mg/5Ml) 60Ml Suspension
-
Description
Co-Amoxiclav 312.5mg/5ml Syrup/Suspension is a combination antibiotic that works by interfering with the synthesis of bacterial cell walls. Amoxicillin, a penicillin-type antibiotic, inhibits the cross-linking of peptidoglycan chains, weakening the cell wall. Clavulanic acid, the second component, inhibits beta-lactamase enzymes produced by bacteria, thereby protecting amoxicillin from degradation and enhancing its antibacterial effect. This dual action effectively combats a wide range of bacteria, including those that have developed resistance to beta-lactam antibiotics. -
Ingredients
Co-Amoxiclav 312.5mg/5ml -
Drug Class
Penicillin combination -
Dosage Form
Suspension -
Uses
The following are the uses of Co-Amoxiclav 312.5mg/5ml Syrup/Suspension:- Used for treating severe respiratory tract infections like pneumonia and bronchitis.
- Used for ear, nose, and throat infections, especially those resistant to common antibiotics.
- Effective against skin and soft tissue infections, including cellulitis and animal bites.
- Used for bone and joint infections, ensuring deep penetration into these tissues.
- Combats certain types of abdominal infections, such as peritonitis and intra-abdominal abscesses.
- Used for prophylaxis in high-risk surgical procedures to prevent post-operative infections.
-
In case of Overdose
In the case of an overdose of Co-Amoxiclav 312.5mg/5ml Syrup/Suspension, it is important to recognize the potential symptoms, which may include gastrointestinal disturbances, such as nausea, vomiting, and diarrhea. Additionally, individuals may experience allergic reactions, with symptoms like rashes, itching, and swelling. Prompt medical attention is necessary, and healthcare professionals should be contacted immediately for guidance and appropriate treatment to manage the overdose effectively. -
Missed Dose
In the case of a missed dose of Co-Amoxiclav 312.5mg/5ml Syrup/Suspension, it is important to administer the missed dose as soon as you remember. If it is almost time for the next dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to make up for a missed one, as this may increase the risk of side effects. It is recommended to take the medication at evenly spaced intervals to maintain an effective level in the body. Consult your healthcare provider if you have any concerns or if you miss multiple doses. -
How To Use
To administer Co-Amoxiclav 312.5mg/5ml Syrup/Suspension, shake the bottle well, use the provided measuring device to draw the prescribed amount, and give it to the patient by mouth, ensuring it is taken as directed by the healthcare provider, typically every 8 hours, regardless of meals. -
When Not to Use
Here are the conditions or situations when Co-Amoxiclav 312.5mg/5ml Syrup/Suspension should not be taken:- Do not use if you have a known allergy to amoxicillin, clavulanic acid, or any other penicillin-based antibiotics.
- Contraindicated in patients with a history of severe allergic reactions to any beta-lactam antibiotics.
- Should not be used in individuals with a previous history of liver problems associated with Co-Amoxiclav or penicillin-based antibiotics.
- Not suitable for patients with mononucleosis.
- Avoid use if you have severe kidney problems, as dosage adjustments are necessary.
- Do not use if you have a history of gastrointestinal diseases, especially colitis, or antibiotic-associated colitis.
-
Side Effects
The side effects of Co-Amoxiclav 312.5mg/5ml Syrup/Suspension may include:- Diarrhea
- Nausea and vomiting
- Skin rash or itching
- Fatigue or drowsiness
- Headache
- Abdominal pain
- Allergic reactions (e.g., hives, difficulty breathing)
- Yeast infections (candidiasis)
-
Precautions & Warnings
Following are the precautions and warnings for Co-Amoxiclav 312.5mg/5ml Syrup/Suspension:- This medication should not be used if you are allergic to any penicillin-type antibiotics or beta-lactamase inhibitors.
- Ensure you complete the full prescribed course of the medication, even if you feel better, to prevent the risk of antibiotic resistance.
- Do not take Co-Amoxiclav if you have a history of severe allergic reactions to any antibiotics, especially penicillins or cephalosporins.
- Caution is advised for patients with kidney or liver problems, as dosage adjustments may be necessary.
- Inform your doctor if you have a history of gastrointestinal issues, such as colitis, as Co-Amoxiclav may aggravate these conditions.
- This medication may reduce the effectiveness of contraceptive pills; consider using additional contraceptive methods while on this treatment.
- If you develop a severe skin rash, hives, or any other signs of an allergic reaction, discontinue use and seek immediate medical attention.
-
Drug Interactions
Following are the drug interactions for Co-Amoxiclav 312.5mg/5ml Syrup/Suspension:- Probenecid and allopurinol can reduce the excretion of amoxicillin, potentially increasing the risk of side effects.
- Co-Amoxiclav may decrease the effectiveness of oral contraceptives, requiring alternative contraceptive methods.
- The risk of bleeding may increase when taken with anticoagulants like warfarin, requiring close monitoring.
- Concurrent use with methotrexate may elevate methotrexate levels, necessitating dosage adjustments.
- When combined with mycophenolate mofetil, Co-Amoxiclav can reduce its effectiveness.
- May decrease the efficacy of live attenuated vaccines, such as the oral polio vaccine.
- Co-administration with certain antibiotics (e.g., chloramphenicol, macrolides) may reduce the effectiveness of Co-Amoxiclav.
-
Food Interactions
Following are the food interactions for Co-Amoxiclav 312.5mg/5ml Syrup/Suspension:- Avoid consuming alcohol during the medication course as it may increase the risk of gastrointestinal side effects and liver toxicity.
- Grapefruit and grapefruit juice should be consumed with caution as they may interfere with the metabolism of the drug, leading to increased levels of amoxicillin in the body and potentially increasing the risk of side effects.
- Dairy products like milk, yogurt, and cheese can reduce the absorption of amoxicillin. It is best to take the medication 1-2 hours before or after consuming dairy.
- High-fat meals can delay the absorption of amoxicillin, so it is recommended to take the medication on an empty stomach or at least 1 hour before a meal.
- Avoid consuming large amounts of caffeinated beverages like coffee or energy drinks, as caffeine may increase the risk of side effects and interact with the medication's effectiveness.
- Vitamin C supplements or citrus fruits rich in vitamin C may reduce the absorption of amoxicillin. Consider spacing the intake of these supplements or fruits from the medication by a few hours.
- Probiotics and fermented foods like yogurt and kefir can help restore healthy gut bacteria that may be disrupted by the antibiotic. Consider including these in your diet during and after the course of medication.
- No specific food restrictions are associated with Co-Amoxiclav, but maintaining a balanced diet is essential to support overall health during the treatment.
-
Storage/Disposal
Co-Amoxiclav 312.5mg/5ml Syrup/Suspension should be stored in a cool and dry environment, ideally at room temperature, ensuring protection from direct sunlight and moisture. Keep the medication securely sealed in its original packaging to maintain its integrity. Avoid storage in bathrooms or areas exposed to heat, as temperature fluctuations can impact the medicine's effectiveness. Dispose of any unused or expired syrup responsibly; refrain from flushing it down the toilet or draining it into the sink. Consult your pharmacist or healthcare professional for appropriate disposal practices. Additionally, ensure the medication is stored safely away from children to prevent accidental consumption.